Plasma Clearance Rates and Renal Clearance of ³H-labeled Cyclic AMP and ³H-labeled Cyclic GMP in the Dog

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Abstract

Previously, in an attempt to understand the mechanisms involved in the regulation of plasma cyclic nucleotides, we measured concentrations of adenosine 3′,5′-monophosphate (cAMP) and guanosine 3′,5′-monophosphate (cGMP) in plasma from selected blood vessels of anesthetized dogs. The observation that the renal venous plasma concentrations of both cyclic nucleotides were less than arterial concentrations suggested that the kidney might be an important site for the elimination of these compounds from plasma and prompted further investigation of the renal handling of these compounds.

Authors

Lawrence Blonde, Robert E. Wehmann, Alton L. Steiner