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Concise Publication Free access | 10.1172/JCI107525

Human Lymphocytes Bear Membrane Receptors for C3b and C3d

Aline Eden, Gary W. Miller, and Victor Nussenzweig

1Department of Pathology, New York University School of Medicine, New York 10016

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1Department of Pathology, New York University School of Medicine, New York 10016

Find articles by Miller, G. in: PubMed | Google Scholar

1Department of Pathology, New York University School of Medicine, New York 10016

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Published December 1, 1973 - More info

Published in Volume 52, Issue 12 on December 1, 1973
J Clin Invest. 1973;52(12):3239–3242. https://doi.org/10.1172/JCI107525.
© 1973 The American Society for Clinical Investigation
Published December 1, 1973 - Version history
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Abstract

Human peripheral blood lymphocytes have membrane receptors for EAC43b (sheep erythrocytes sensitized with antibody and complement) and also for EAC43d, obtained by treating EAC43b with C3b inactivator. Human granulocytes bind only EAC43b, C3 fragments obtained by limited trypsin digestion of purified human C3 display both C3b and C3d sites, since they inhibit rosette formation of lymphocytes with EAC43b and EAC43d. These findings raise the possibility that C3b and C3d receptor sites may be selectively distributed among normal subpopulations of B lymphocytes as well as among leukemic leukocytes.

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