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Concise Publication Free access | 10.1172/JCI107523

Utilization of Acetate in the Human Forearm during Exercise after Ethanol Ingestion

F. Lundquist, L. Sestoft, S. E. Damgaard, J. P. Clausen, and J. Trap-Jensen

Department of Biochemistry A, University of Copenhagen, Copenhagen, Denmark

Department of Biochemistry, University of Odense, Copenhagen, Denmark

Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark

Find articles by Lundquist, F. in: PubMed | Google Scholar

Department of Biochemistry A, University of Copenhagen, Copenhagen, Denmark

Department of Biochemistry, University of Odense, Copenhagen, Denmark

Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark

Find articles by Sestoft, L. in: PubMed | Google Scholar

Department of Biochemistry A, University of Copenhagen, Copenhagen, Denmark

Department of Biochemistry, University of Odense, Copenhagen, Denmark

Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark

Find articles by Damgaard, S. in: PubMed | Google Scholar

Department of Biochemistry A, University of Copenhagen, Copenhagen, Denmark

Department of Biochemistry, University of Odense, Copenhagen, Denmark

Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark

Find articles by Clausen, J. in: PubMed | Google Scholar

Department of Biochemistry A, University of Copenhagen, Copenhagen, Denmark

Department of Biochemistry, University of Odense, Copenhagen, Denmark

Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark

Find articles by Trap-Jensen, J. in: PubMed | Google Scholar

Published December 1, 1973 - More info

Published in Volume 52, Issue 12 on December 1, 1973
J Clin Invest. 1973;52(12):3231–3235. https://doi.org/10.1172/JCI107523.
© 1973 The American Society for Clinical Investigation
Published December 1, 1973 - Version history
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Abstract

The uptake of acetate in the human forearm was studied in five fasting (14 h) subjects during 10-min periods of ergometer work at 7 and 10 kilopond-meters per minute (kpm/min). A constant arterial acetate concentration was established by administration of a small quantity of alcohol (25 g) to the subjects after a control work period. Blood flow was measured by an indicator dilution technique. Acetate uptake varied linearly with the product of arterial acetate concentration and blood flow. Acetate metabolism was calculated to account for about 6.5% of the energy metabolism, assuming complete combustion to carbon dioxide and water. Oxygen uptake and blood flow did not change in the presence of acetate and ethanol.

After administration of ethanol the arterial concentrations of FFA and glycerol decreased to about half, whereas the lactate concentration increased to about twice the control values, confirming other reports.

Glucose utilization was increased and lactate output decreased during the ethanol periods, presumably a consequence of the changing arterial concentrations and increased insulin level. Measurements of the arterial and venous lactate/pyruvate concentration ratios indicate that the NAD-mediated cytoplasmic redox state in the muscle is not changed in the presence of acetate and ethanol.

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