Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Next-Generation Sequencing in Medicine (Upcoming)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI107521

The Role of Blood Osmolality and Volume in Regulating Vasopressin Secretion in the Rat

Fredrick L. Dunn, Thomas J. Brennan, Averial E. Nelson, and Gary L. Robertson

Department of Medicine, Indiana University Medical Center and the Veterans Administration Hospital, Indianapolis, Indiana 46202

Abraham Lincoln School of Medicine and Veterans Administration West Side Hospital, Chicago, Illinois 60680

Find articles by Dunn, F. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University Medical Center and the Veterans Administration Hospital, Indianapolis, Indiana 46202

Abraham Lincoln School of Medicine and Veterans Administration West Side Hospital, Chicago, Illinois 60680

Find articles by Brennan, T. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University Medical Center and the Veterans Administration Hospital, Indianapolis, Indiana 46202

Abraham Lincoln School of Medicine and Veterans Administration West Side Hospital, Chicago, Illinois 60680

Find articles by Nelson, A. in: JCI | PubMed | Google Scholar

Department of Medicine, Indiana University Medical Center and the Veterans Administration Hospital, Indianapolis, Indiana 46202

Abraham Lincoln School of Medicine and Veterans Administration West Side Hospital, Chicago, Illinois 60680

Find articles by Robertson, G. in: JCI | PubMed | Google Scholar

Published December 1, 1973 - More info

Published in Volume 52, Issue 12 on December 1, 1973
J Clin Invest. 1973;52(12):3212–3219. https://doi.org/10.1172/JCI107521.
© 1973 The American Society for Clinical Investigation
Published December 1, 1973 - Version history
View PDF
Abstract

A sensitive and specific radioimmunoassay for plasma arginine vasopressin (AVP) has been used to study the effects of blood osmolality and volume in regulating AVP secretion in unanesthetized rats. Under basal conditions, plasma AVP and osmolality were relatively constant, averaging 2.3±0.9 (SD) pg/ml and 294±1.4 mosmol/kg, respectively. Fluid restriction, which increased osmolality and decreased volume, resulted in a progressive rise in plasma AVP to about 10 times basal levels after 96 h. A 2-3-fold increase in plasma AVP occurred as early as 12 h, when osmolality and volume had each changed by less than 2%. Intraperitoneal injections of hypertonic saline, which had no effect on blood volume, also produced a rise in plasma AVP that was linearly correlated with the rise in osmolality (r > 0.9) and quantitatively similar to that found during fluid restriction (plasma AVP increased 2-4-fold with each 1% increase in osmolality). Intraperitoneal injection of polyethylene glycol, which decreased blood volume without altering osmolality, also increased plasma AVP but this response followed an exponential pattern and did not become significant until volume had decreased by 8% or more. At these levels of hypovolemia, the osmoregulatory system continued to function but showed a lower threshold and increase sensitivity to osmotic stimulation. We conclude that AVP secretion is regulated principally by blood osmolality but that the responsiveness of this mechanism may be significantly altered by modest changes in blood volume.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 3212
page 3212
icon of scanned page 3213
page 3213
icon of scanned page 3214
page 3214
icon of scanned page 3215
page 3215
icon of scanned page 3216
page 3216
icon of scanned page 3217
page 3217
icon of scanned page 3218
page 3218
icon of scanned page 3219
page 3219
Version history
  • Version 1 (December 1, 1973): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts