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Research Article Free access | 10.1172/JCI107436

Inhibition of Liver Fibrosis by L-Azetidine-2-Carboxylic Acid in Rats Treated with Carbon Tetrachloride

Marcos Rojkind

1Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN, México 14, D. F.

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Published October 1, 1973 - More info

Published in Volume 52, Issue 10 on October 1, 1973
J Clin Invest. 1973;52(10):2451–2456. https://doi.org/10.1172/JCI107436.
© 1973 The American Society for Clinical Investigation
Published October 1, 1973 - Version history
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Abstract

L-Azetidine-2-carboxylic acid (AZC), an analogue of proline, has been shown to partially ameliorate hepatic cirrhosis induced in rats by CCl4. AZC caused a diminution in formation of collagen in the liver accompanied by a relative decrease in the pool of free proline. The synthesis of noncollagenous proteins in the livers of treated rats did not appear to be affected.

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