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Concise Publication Free access | 10.1172/JCI107426

Cyclic AMP and Sodium Transport: QUANTITATIVE AND TEMPORAL RELATIONSHIPS IN TOAD URINARY BLADDER

Victor S. Sapirstein and Walter N. Scott

Department of Ophthalmology, Mount Sinai School of Medicine of The City University of New York, New York 10029

Department of Physiology, Mount Sinai School of Medicine of The City University of New York, New York 10029

Find articles by Sapirstein, V. in: PubMed | Google Scholar

Department of Ophthalmology, Mount Sinai School of Medicine of The City University of New York, New York 10029

Department of Physiology, Mount Sinai School of Medicine of The City University of New York, New York 10029

Find articles by Scott, W. in: PubMed | Google Scholar

Published September 1, 1973 - More info

Published in Volume 52, Issue 9 on September 1, 1973
J Clin Invest. 1973;52(9):2379–2382. https://doi.org/10.1172/JCI107426.
© 1973 The American Society for Clinical Investigation
Published September 1, 1973 - Version history
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Abstract

The effects of oxytocin upon tissue cAMP content and short-circuit current (SCC) were measured in the urinary bladder of the toad, Bufo marinus. Tissue cAMP levels doubled before any increment in SCC was observed, the two hormone responses were quantitatively related, and a threshold level for an effect of cAMP upon sodium transport was demonstrated. The period of time over which cAMP levels continued to rise after the threshold level had been attained seemed invariant with hormone concentration. The rate at which cAMP levels rose increased with hormone concentration yielding hormone concentration-dependent maximal levels. The decay of cAMP levels was delayed when sodium influx was curtailed, suggesting a sodium-regulatory effect upon tissue cAMP levels.

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