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Usage Information

Effective Erythropoiesis Induced by 5β-Pregnane-3β-Hydroxy-20-One in Squirrel Monkeys
Emmanuel C. Besa, … , William A. Hait, Frank H. Gardner
Emmanuel C. Besa, … , William A. Hait, Frank H. Gardner
Published September 1, 1973
Citation Information: J Clin Invest. 1973;52(9):2278-2282. https://doi.org/10.1172/JCI107415.
View: Text | PDF
Research Article

Effective Erythropoiesis Induced by 5β-Pregnane-3β-Hydroxy-20-One in Squirrel Monkeys

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Abstract

The erythropoietic effect of 5β-pregnane-3β-hydroxy-20-one, a naturally occurring steroid metabolite of progesterone, was evaluated in the squirrel monkey by ferrokinetic studies. red cell survival, and blood volume measurements. The intramuscular administration of this steroid in pharmacologic doses shortened the 59Fe plasma clearance and increased the plasma iron turnover, thereby indicating an increase in erythropoiesis. A normal 59Fe red cell uptake was observed, and the bone marrow maturation time was not altered. Red cell survival was the same in the treated and control groups. After five weekly injections of the steroid, the monkeys increased their red cell mass by 57%. A significant increase in white blood cells and a slight elevation of platelet counts in the treated monkeys also suggest a possible direct stimulation of hemopoietic stem cells by the steroid metabolite.

Authors

Emmanuel C. Besa, Dov Gorshein, William A. Hait, Frank H. Gardner

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 69 0
PDF 42 13
Scanned page 161 1
Citation downloads 43 0
Totals 315 14
Total Views 329
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