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Research Article Free access | 10.1172/JCI107324

Dynamics of Glomerular Ultrafiltration in the Rat. IV. DETERMINATION OF THE ULTRAFILTRATION COEFFICIENT

William M. Deen, Julia L. Troy, Channing R. Robertson, and Barry M. Brenner

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Department of Chemical Engineering, Stanford University, Stanford, California 94305

Find articles by Deen, W. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Department of Chemical Engineering, Stanford University, Stanford, California 94305

Find articles by Troy, J. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Department of Chemical Engineering, Stanford University, Stanford, California 94305

Find articles by Robertson, C. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Department of Chemical Engineering, Stanford University, Stanford, California 94305

Find articles by Brenner, B. in: PubMed | Google Scholar

Published June 1, 1973 - More info

Published in Volume 52, Issue 6 on June 1, 1973
J Clin Invest. 1973;52(6):1500–1508. https://doi.org/10.1172/JCI107324.
© 1973 The American Society for Clinical Investigation
Published June 1, 1973 - Version history
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Abstract

Pressures and flow rates were measured in accessible surface glomeruli of mutant Wistar rats under conditions deliberately designed to prevent achievement of filtration pressure equilibrium, that is, the equalization of transcapillary hydrostatic and oncotic pressures by the efferent end of the glomerulus as typically observed in the normal hydropenic rat. Disequilibrium was obtained at elevated levels of glomerular plasma flow (GPF) brought about by acute expansion of plasma volume with a volume of rat plasma equal to 5% of body weight. Glomerular hydrostatic and oncotic pressures measured at high GPF were used to calculate the ultrafiltration coefficient, Kf, the product of effective hydraulic permeability and surface area. GPF was then either lowered (by aortic constriction) or raised (by carotid occlusion) in order to examine the dependence of Kf on GPF. The value of Kf per glomerulus, 0.08 nl/(s·mm Hg), was found not to vary over an approximately twofold range of GPF. This finding, taken together with data from previous studies from this laboratory, leads us to conclude that plasma-flow dependence of glomerular filtration rate (GFR) results primarily from flow-induced changes in mean ultrafiltration pressure, rather than large changes in Kf.

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