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Research Article Free access | 10.1172/JCI107284
Thorndike Memorial Laboratory, Boston City Hospital, Boston 02118
Harvard Medical Services, Boston City Hospital, Boston 02118
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
Find articles by Kim, C. in: JCI | PubMed | Google Scholar
Thorndike Memorial Laboratory, Boston City Hospital, Boston 02118
Harvard Medical Services, Boston City Hospital, Boston 02118
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
Find articles by Tilles, J. in: JCI | PubMed | Google Scholar
Published May 1, 1973 - More info
Hepatitis B antigen (HB Ag) has been purified from serum by pepsin digestion and equilibrium sedimentation. The sedimentation coefficient, density, particle size, and electrophoretic mobility have been determined before and after purification and found to be unaltered. In addition, the diffusion constant and molecular weight of purified HB Ag have been documented.
Because the biophysical characteristics found are not consistant with those of any known virus, it is believed that native HB Ag is made up almost entirely of incomplete virus.
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