Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts

J. J. McPhaul; A. L. Thompson; Robert E. Lordon; G. Klebanoff; A. B. Cosimi; R. DeLemos; R. B. Smith

doi:10.1172/JCI107271

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by McPhaul, J. in: PubMed | Google Scholar

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by Thompson, A. in: PubMed | Google Scholar

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by Lordon, R. in: PubMed | Google Scholar

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by Klebanoff, G. in: PubMed | Google Scholar

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by Cosimi, A. in: PubMed | Google Scholar

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by DeLemos, R. in: PubMed | Google Scholar

^{Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Pediatrics, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Department of Surgery, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

^{Clinical Research Laboratory, Wilford Hall USAF Medical Center (AFSC), Lackland AFB, Texas 78236}

Find articles by Smith, R. in: PubMed | Google Scholar

Published in Volume 52, Issue 5 on May 1, 1973
J Clin Invest. 1973;52(5):1059–1066. https://doi.org/10.1172/JCI107271.
© 1973 The American Society for Clinical Investigation

Published May 1, 1973 - Version history

Direct immunofluorescent (IF) examinations and elutions were performed on native kidneys and allografts of 24 patients undergoing renal transplantation. Immunoglobulins (Ig) were detected by IF on native kidneys of 12 of the 24; 11 of the 12 later had Ig localized to allograft glomeruli by direct IF. In addition, three other patients also developed Ig deposition on allograft glomeruli, although direct IF of native kidneys was negative. Elution studies indicated: (a) that linear Ig deposition on allograft glomeruli was the result of antiglomerular basement membrane (GBM) antibodies, (b) Ig localizing to allograft glomeruli in many of these patients was the result of persistent immunopathogenetic mechanisms existing at the time of allograft placement, and (c) occasionally, kidneys negative for Ig localization by direct IF contain elutable nephritogenic antibodies.

Version 1 (May 1, 1973): No description

Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts

J. J. McPhaul Jr., A. L. Thompson Jr., Robert E. Lordon, G. Klebanoff, A. B. Cosimi, R. DeLemos, and R. B. Smith

Article tools

Metrics

Go to

Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts

J. J. McPhaul Jr., A. L. Thompson Jr., Robert E. Lordon, G. Klebanoff, A. B. Cosimi, R. DeLemos, and R. B. Smith

Article tools

Metrics

Go to

Sign up for email alerts