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Concise Publication Free access | 10.1172/JCI107261

Evidence for Stimulation of Renal Gluconeogenesis by Catecholamines

Kiyoshi Kurokawa and Shaul G. Massry

Renal and Hypertension Service, the Department of Medicine, and the Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048

Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90048

Find articles by Kurokawa, K. in: PubMed | Google Scholar

Renal and Hypertension Service, the Department of Medicine, and the Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048

Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90048

Find articles by Massry, S. in: PubMed | Google Scholar

Published April 1, 1973 - More info

Published in Volume 52, Issue 4 on April 1, 1973
J Clin Invest. 1973;52(4):961–964. https://doi.org/10.1172/JCI107261.
© 1973 The American Society for Clinical Investigation
Published April 1, 1973 - Version history
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Abstract

Isoproterenol and norepinephrine (10-4 M) significantly increased cyclic AMP formation and glucose production by the isolated tubules of the renal cortex of the rat. These effects were abolished by propranolol. Theophylline diminished the effects of the catecholamines on gluconeogenesis despite a marked augmentation in cyclic AMP concentration. In the absence of calcium ion in the incubation medium, isoproterenol stimulates cyclic AMP production, but has no effect on gluconeogenesis. It is concluded that catecholamines enhance gluconeogenesis in renal cortical tubules by the stimulation of beta adrenergic receptors. This effect is probably mediated through adenyl cyclase-cyclic AMP system and requires an adequate level of ATP and the presence of calcium ion.

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