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Usage Information

Effects of a False Neurotransmitter, p-Hydroxynorephedrine, on the Function of Adrenergic Neurons in Hypertensive Patients
Robert E. Rangno, … , J. Throck Watson, John Oates
Robert E. Rangno, … , J. Throck Watson, John Oates
Published April 1, 1973
Citation Information: J Clin Invest. 1973;52(4):952-960. https://doi.org/10.1172/JCI107260.
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Research Article

Effects of a False Neurotransmitter, p-Hydroxynorephedrine, on the Function of Adrenergic Neurons in Hypertensive Patients

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Abstract

Previous studies have shown that amphetamine and p-hydroxyamphetamine impair adrenergic transmission, and it has been suggested that this effect is mediated by an active metabolite, p-hydroxynorephedrine (PHN). Studies in experimental animals have shown that PHN can deplete and substitute for norepinephrine (NE) in the transmitter pool, thus meeting the criteria of a false neurotransmitter.

Authors

Robert E. Rangno, John S. Kaufmann, John H. Cavanaugh, Donald Island, J. Throck Watson, John Oates

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 221 17
PDF 76 15
Figure 0 3
Scanned page 389 11
Citation downloads 85 0
Totals 771 46
Total Views 817
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