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Research Article Free access | 10.1172/JCI107247

Comparative Effects of Angiotensin and ACTH on Cyclic AMP and Steroidogenesis in Isolated Bovine Adrenal Cells

Andre Peytremann, Wendell E. Nicholson, Ronald D. Brown, Grant W. Liddle, and Joel G. Hardman

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Peytremann, A. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Nicholson, W. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Brown, R. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Liddle, G. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Hardman, J. in: JCI | PubMed | Google Scholar

Published April 1, 1973 - More info

Published in Volume 52, Issue 4 on April 1, 1973
J Clin Invest. 1973;52(4):835–842. https://doi.org/10.1172/JCI107247.
© 1973 The American Society for Clinical Investigation
Published April 1, 1973 - Version history
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Abstract

The comparative effects of angiotensin II and adrenocorticotropic hormone (ACTH) on cyclic AMP and steroidogenesis were investigated employing isolated bovine adrenal cells from the zona fasciculata. Like ACTH, angiotensin produced a prompt increase in cyclic AMP which preceded the increase in corticosteroid production. Although this increase in cyclic AMP was small when compared to that induced by ACTH, it correlated with the amount of steroidogenesis. This observation is consistent with the view that cyclic AMP is the intracellular mediator of the steroidogenic action of angiotensin.

Angiotensin acted synergistically with ACTH on cyclic AMP levels. This synergism was not explained by inhibition of phosphodiesterase activity. Unlike ACTH, angiotensin failed to stimulate adenylate cyclase in broken cell preparations. The observations suggest that more than one mechanism may be involved in effects of ACTH and angiotensin on cyclic AMP levels.

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