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Usage Information

Pathogenesis of Salmonellosis STUDIES OF FLUID SECRETION, MUCOSAL INVASION, AND MORPHOLOGIC REACTION IN THE RABBIT ILEUM
R. A. Giannella, … , G. J. Dammin, H. Collins
R. A. Giannella, … , G. J. Dammin, H. Collins
Published February 1, 1973
Citation Information: J Clin Invest. 1973;52(2):441-453. https://doi.org/10.1172/JCI107201.
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Research Article

Pathogenesis of Salmonellosis STUDIES OF FLUID SECRETION, MUCOSAL INVASION, AND MORPHOLOGIC REACTION IN THE RABBIT ILEUM

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Abstract

Strains of Salmonella typhimurium were studied in the ligated rabbit ileal loop model to gain insight into the mechanisms whereby bacteria which invade the gastrointestinal mucosa evoke fluid exsorption. The organisms employed differed in various biologic attributes including the ability to invade the ileal epithelium, multiply within the mucosa, elicit an acute inflammatory reaction, and disseminate across the intestinal wall. Some strains provoked small intestinal fluid exsorption although these did not elaborate enterotoxin. Only those strains which invaded the mucosa were accompanied by either mucosal inflammation or fluid exsorption. Noninvasive strains produced neither histologic abnormalities nor fluid secretion. While strains which invaded the mucosa caused an acute inflammatory reaction, not all such strains evoked fluid secretion. Furthermore, there was no correlation in ability of invasive organisms to evoke fluid secretion or in the intensity of mucosal inflammation, number of intramucosal salmonellae, or in ability to disseminate from the rabbit ileum.

Authors

R. A. Giannella, S. B. Formal, G. J. Dammin, H. Collins

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 278 29
PDF 57 17
Figure 0 1
Scanned page 468 10
Citation downloads 56 0
Totals 859 57
Total Views 916
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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