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Free access | 10.1172/JCI107061
Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
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Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Find articles by Friedman, S. in: JCI | PubMed | Google Scholar
Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Find articles by Wilson, D. in: JCI | PubMed | Google Scholar
Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Find articles by Lees, R. in: JCI | PubMed | Google Scholar
Published September 1, 1972 - More info
To investigate the interaction of lipoproteins with semipermeable membranes, solutions of low density lipoproteins (LDL), very low density lipoproteins (VLDL), mixtures of the two, and diluted, normal, and hyperlipidemic serum were ultrafiltered through a synthetic membrane (500 A nominal pore diameter) using a stirred laboratory ultrafiltration cell. The pressure dependence of ultrafiltrate flux showed that a concentrated layer of lipoproteins was built up at the membrane surface (concentration polarization) and that VLDL was more subject to polarization than LDL. This phenomenon controlled the observed lipoprotein transport behavior. Whereas true membrane rejection (the fraction of the solute on the membrane surface which does not pass through the membrane) was greater than 0.95 for both LDL and VLDL, observed solute rejection varied from nearly 0 to 1.0, depending upon experimental conditions.
If concentration polarization occurs in the arterial system, these results suggest that lipoprotein transport into arterial wall may be influenced not only by arterial blood pressure and the properties of the arterial wall, but also by local hemodynamic conditions and by the relative as well as absolute magnitudes of LDL and VLDL concentration.