Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Free access | 10.1172/JCI107061

Ultrafiltration of lipoproteins through a synthetic membrane: Implications for the filtration theory of atherogenesis

Clark K. Colton, Sigmund Friedman, Dana E. Wilson, and Robert S. Lees

Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Find articles by Colton, C. in: JCI | PubMed | Google Scholar

Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Find articles by Friedman, S. in: JCI | PubMed | Google Scholar

Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Find articles by Wilson, D. in: JCI | PubMed | Google Scholar

Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Find articles by Lees, R. in: JCI | PubMed | Google Scholar

Published September 1, 1972 - More info

Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2472–2481. https://doi.org/10.1172/JCI107061.
© 1972 The American Society for Clinical Investigation
Published September 1, 1972 - Version history
View PDF
Abstract

To investigate the interaction of lipoproteins with semipermeable membranes, solutions of low density lipoproteins (LDL), very low density lipoproteins (VLDL), mixtures of the two, and diluted, normal, and hyperlipidemic serum were ultrafiltered through a synthetic membrane (500 A nominal pore diameter) using a stirred laboratory ultrafiltration cell. The pressure dependence of ultrafiltrate flux showed that a concentrated layer of lipoproteins was built up at the membrane surface (concentration polarization) and that VLDL was more subject to polarization than LDL. This phenomenon controlled the observed lipoprotein transport behavior. Whereas true membrane rejection (the fraction of the solute on the membrane surface which does not pass through the membrane) was greater than 0.95 for both LDL and VLDL, observed solute rejection varied from nearly 0 to 1.0, depending upon experimental conditions.

If concentration polarization occurs in the arterial system, these results suggest that lipoprotein transport into arterial wall may be influenced not only by arterial blood pressure and the properties of the arterial wall, but also by local hemodynamic conditions and by the relative as well as absolute magnitudes of LDL and VLDL concentration.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2472
page 2472
icon of scanned page 2473
page 2473
icon of scanned page 2474
page 2474
icon of scanned page 2475
page 2475
icon of scanned page 2476
page 2476
icon of scanned page 2477
page 2477
icon of scanned page 2478
page 2478
icon of scanned page 2479
page 2479
icon of scanned page 2480
page 2480
icon of scanned page 2481
page 2481
Version history
  • Version 1 (September 1, 1972): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts