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Research Article Free access | 10.1172/JCI107044

An evaluation of antibodies and clinical resistance to salmon calcitonin

Frederick R. Singer, J. Phillip Aldred, Robert M. Neer, Stephen M. Krane, John T. Potts, and Kurt J. Bloch

Department of Medicine, Massachusetts General Hospital, Boston 02114

West Roxbury Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Harvard Medical School, Boston 02115

Armour Pharmaceutical Co., Kankakee, Illinois 60901

Find articles by Singer, F. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114

West Roxbury Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Harvard Medical School, Boston 02115

Armour Pharmaceutical Co., Kankakee, Illinois 60901

Find articles by Aldred, J. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114

West Roxbury Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Harvard Medical School, Boston 02115

Armour Pharmaceutical Co., Kankakee, Illinois 60901

Find articles by Neer, R. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114

West Roxbury Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Harvard Medical School, Boston 02115

Armour Pharmaceutical Co., Kankakee, Illinois 60901

Find articles by Krane, S. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114

West Roxbury Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Harvard Medical School, Boston 02115

Armour Pharmaceutical Co., Kankakee, Illinois 60901

Find articles by Potts, J. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114

West Roxbury Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Harvard Medical School, Boston 02115

Armour Pharmaceutical Co., Kankakee, Illinois 60901

Find articles by Bloch, K. in: PubMed | Google Scholar

Published September 1, 1972 - More info

Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2331–2338. https://doi.org/10.1172/JCI107044.
© 1972 The American Society for Clinical Investigation
Published September 1, 1972 - Version history
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Abstract

21 patients with Paget's disease of bone and one with osteoporosis were studied to detect development of antibodies to salmon calcitonin during chronic therapy. Antibody titers ranged from 1:40 to 1:30,000 in plasma obtained after treatment of 11 patients. Radio-immunoelectrophoresis revealed that the antibodies were restricted to the γG class. One patient, W. O., with Paget's disease initially responded to treatment with a decrease in bone turnover, but later became resistant to the hormone in association with the appearance of a very high titer (1:30,000) of antibody against salmon calcitonin. A 1:10 dilution of his plasma was shown to completely inactivate 20 mMRC units/ml of salmon calcitonin as detected by bioassay in rats; slight inactivation was detected at a 1:200 dilution. All other patients continued to respond to salmon calcitonin despite the development of antibody to the hormone in ten cases. No evidence of systemic allergic reactions or other toxicity was found in any patient. The data suggest that although antibody formation may occur in as many as 50% of patients treated with salmon calcitonin, this antibody response is unlikely to be of clinical significance in most patients. However, in an occasional patient, a marked antibody response may occur which interferes with the therapeutic use of the hormone.

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