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Research Article Free access | 10.1172/JCI107032

Adrenocortical steroidogenesis: studies on the mechanism of action of angiotensin and electrolytes

Takao Saruta, Robert Cook, and Norman M. Kaplan

Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235

Find articles by Saruta, T. in: JCI | PubMed | Google Scholar

Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235

Find articles by Cook, R. in: JCI | PubMed | Google Scholar

Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235

Find articles by Kaplan, N. in: JCI | PubMed | Google Scholar

Published September 1, 1972 - More info

Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2239–2245. https://doi.org/10.1172/JCI107032.
© 1972 The American Society for Clinical Investigation
Published September 1, 1972 - Version history
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Abstract

The effects of adrenocorticotropin (ACTH), angiotensins I and II, increased potassium, and decreased sodium concentrations upon steroid synthesis were examined by incubation of beef adrenal tissue slices.

Angiotensin II shared with ACTH the need for calcium and an inhibition of its effect in the presence of puromycin but differed in not stimulating cyclic adenosine monophosphate (AMP). Angiotensin I was effective in steroidogenesis. The stimulation of aldosterone synthesis by increased potassium concentration was accompanied by an increased level of cyclic AMP and was inhibited in the presence of puromycin. Decreased sodium concentration stimulated aldosterone synthesis but, alone of these stimuli, simultaneously decreased corticosterone levels.

It therefore appears that ACTH and potassium stimulate steroidogenesis at an early step in the biosynthetic pathway through the activation of cyclic AMP, whereas the effect of angiotensins I and II involve another mechanism and decreased sodium concentration affects a later step in steroidogenesis.

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