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Usage Information

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
Terry Langer, Warren Strober, Robert I. Levy
Terry Langer, Warren Strober, Robert I. Levy
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Research Article

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

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Abstract

The metabolism of low density lipoprotein (LDL, beta lipoprotein) was studied in 10 normal individuals and 10 patients with familial type II hyperlipoproteinemia using purified radioiodinated LDL. Over 97% of the label was bound to the protein moiety of LDL and therefore the turnover data reflect the fate and distribution of LDL-apoprotein. Comparison of the metabolic behavior of biologically screened and unscreened labeled LDL preparations in dogs as well as the analysis of the urinary excretion of radioiodide derived from labeled LDL degradation in humans indicated that no significant denaturation resulted from the isolation, purification, and labeling techniques.

Authors

Terry Langer, Warren Strober, Robert I. Levy

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
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PDF 174 16
Scanned page 622 1
Citation downloads 163 0
Totals 1,457 44
Total Views 1,501
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ISSN: 0021-9738 (print), 1558-8238 (online)

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