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Usage Information

Renal handling of sodium and water in the hypothyroid rat: Clearance and micropuncture studies
Ulrich F. Michael, Robert L. Barenberg, Rafaelita Chavez, Carlos A. Vaamonde, Solomon Papper
Ulrich F. Michael, Robert L. Barenberg, Rafaelita Chavez, Carlos A. Vaamonde, Solomon Papper
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Renal handling of sodium and water in the hypothyroid rat: Clearance and micropuncture studies

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Abstract

Hypothyroid rats were examined with conventional renal clearance and micropuncture techniques to elicit the mechanism and site within the nephron responsible for the increased salt and water excretion observed in these animals. When compared with age-matched control rats, a decrease in inulin clearance of 30% (P < 0.001) and in Hippuran clearance of 32% (P < 0.005) was observed in the hypothyroid rats. Absolute excretion of sodium and water was increased 3-fold (P < 0.02) and 2-fold (P < 0.025), respectively, while fractional excretion of sodium and water was increased 4.3-fold (P < 0.02) and 2.9-fold (P < 0.05), respectively, in the hypothyroid animals.

Authors

Ulrich F. Michael, Robert L. Barenberg, Rafaelita Chavez, Carlos A. Vaamonde, Solomon Papper

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 330 14
PDF 134 12
Scanned page 550 2
Citation downloads 170 0
Totals 1,184 28
Total Views 1,212
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ISSN: 0021-9738 (print), 1558-8238 (online)

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