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Research Article Free access | 10.1172/JCI106811

Long-Term Kinetics of Serum and Xanthoma Cholesterol Radioactivity in Patients with Hypercholesterolemia

Paul Samuel, William Perl, Charles M. Holtzman, Norman D. Rochman, and Sidney Lieberman

Department of Medicine, The Long Island Jewish Medical Center, New Hyde Park, New York 11040

Department of Medicine, The Long Island Jewish Medical Center— Queens Hospital Center Affiliation, Jamaica, New York 11432

Department of Medicine, The College of Medicine and Dentistry of New Jersey at Newark, Newark, New Jersey 07103

Department of Chemistry, Queens College of The City University of New York, Flushing, New York 11367

Department of Mathematics, Queens College of The City University of New York, Flushing, New York 11367

Find articles by Samuel, P. in: PubMed | Google Scholar

Department of Medicine, The Long Island Jewish Medical Center, New Hyde Park, New York 11040

Department of Medicine, The Long Island Jewish Medical Center— Queens Hospital Center Affiliation, Jamaica, New York 11432

Department of Medicine, The College of Medicine and Dentistry of New Jersey at Newark, Newark, New Jersey 07103

Department of Chemistry, Queens College of The City University of New York, Flushing, New York 11367

Department of Mathematics, Queens College of The City University of New York, Flushing, New York 11367

Find articles by Perl, W. in: PubMed | Google Scholar

Department of Medicine, The Long Island Jewish Medical Center, New Hyde Park, New York 11040

Department of Medicine, The Long Island Jewish Medical Center— Queens Hospital Center Affiliation, Jamaica, New York 11432

Department of Medicine, The College of Medicine and Dentistry of New Jersey at Newark, Newark, New Jersey 07103

Department of Chemistry, Queens College of The City University of New York, Flushing, New York 11367

Department of Mathematics, Queens College of The City University of New York, Flushing, New York 11367

Find articles by Holtzman, C. in: PubMed | Google Scholar

Department of Medicine, The Long Island Jewish Medical Center, New Hyde Park, New York 11040

Department of Medicine, The Long Island Jewish Medical Center— Queens Hospital Center Affiliation, Jamaica, New York 11432

Department of Medicine, The College of Medicine and Dentistry of New Jersey at Newark, Newark, New Jersey 07103

Department of Chemistry, Queens College of The City University of New York, Flushing, New York 11367

Department of Mathematics, Queens College of The City University of New York, Flushing, New York 11367

Find articles by Rochman, N. in: PubMed | Google Scholar

Department of Medicine, The Long Island Jewish Medical Center, New Hyde Park, New York 11040

Department of Medicine, The Long Island Jewish Medical Center— Queens Hospital Center Affiliation, Jamaica, New York 11432

Department of Medicine, The College of Medicine and Dentistry of New Jersey at Newark, Newark, New Jersey 07103

Department of Chemistry, Queens College of The City University of New York, Flushing, New York 11367

Department of Mathematics, Queens College of The City University of New York, Flushing, New York 11367

Find articles by Lieberman, S. in: PubMed | Google Scholar

Published February 1, 1972 - More info

Published in Volume 51, Issue 2 on February 1, 1972
J Clin Invest. 1972;51(2):266–278. https://doi.org/10.1172/JCI106811.
© 1972 The American Society for Clinical Investigation
Published February 1, 1972 - Version history
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Abstract

In four patients with hypercholesterolemia (type II hyperlipoproteinemia) and xanthomatosis the decay of serum cholesterol specific activity was followed for 53-63 wk after pulse labeling. Specific activity of biopsied xanthoma cholesterol was measured four times in the course of the study. The xanthoma specific activity curve crossed and thereafter remained above the serum specific activity curve. The average ratio of xanthoma to serum specific activity was 4.7 at the end of the study. The final half-time of the xanthoma decay curves was significantly greater (average: 200 days) than the slowest half-time of serum specific activity decay (average: 93 days). The data were analyzed by input-output analysis and yielded the following results. The average value for the total input rate of body cholesterol (IT) (sum of dietary and biosynthesized cholesterol) was 1.29 g/day. The average size of the rapidly miscible pool of cholesterol (Ma) was 55.7 g. and of the total exchangeable body mass of cholesterol (M) 116.5 g. The average value of M - Ma (remaining exchangeable mass of cholesterol) was 60.8 g. The derived values for exchangeable masses of cholesterol, in the present patients with marked hypercholesterolemia, were significantly larger than in a group of patients with normal serum lipids in previous studies. One of the four patients died of a sudden acute myocardial infarction 53 wk after pulse labeling. Specific activity of aortic wall and atheroma cholesterol was 3.12 times that of serum. The ratio was close to 2 for adipose tissue and spleen, and was slightly above 1 or was close to unity in most other organs studied, with the exception of brain which showed a ratio of 0.19.

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