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Research Article Free access | 10.1172/JCI106793

Human Serum Activities against Hemophilus influenzae, Type b

Porter Anderson, Richard B. Johnston Jr., and David H. Smith

Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115

Division of Immunology, Children's Hospital Medical Center, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Anderson, P. in: PubMed | Google Scholar

Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115

Division of Immunology, Children's Hospital Medical Center, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Johnston, R. in: PubMed | Google Scholar

Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115

Division of Immunology, Children's Hospital Medical Center, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Smith, D. in: PubMed | Google Scholar

Published January 1, 1972 - More info

Published in Volume 51, Issue 1 on January 1, 1972
J Clin Invest. 1972;51(1):31–38. https://doi.org/10.1172/JCI106793.
© 1972 The American Society for Clinical Investigation
Published January 1, 1972 - Version history
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Abstract

Humoral immunity to Hemophilus influenzae, type b was studied in normal human adults by means of assays for serum bactericidal and opsonizing activities against the organism and for passive hemagglutinating activity using erythrocytes sensitized with polyribophosphate, the type-specific capsular antigen. Hemagglutinating activity was detectable in about 60% of the 114 sera tested. Serum bactericidal and opsonizing activities were found in all sera tested; the levels in some sera, however, were quite low. The antibacterial activities were due not only to antibodies directed against the polyribophosphate capsule but also to antibodies that appear to be directed against somatic antigens. Type b strains differed in their susceptibility to the antisomatic antibodies of particular sera but were uniformly sensitive to anticapsular antibody.

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