Relationship of nervous tissue transketolase to the neuropathy in chronic uremia

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Abstract

Patients with chronic uremia develop neurologic defects which are similar to the demyelinating lesions seen in thiamine deficiency. The present study describes inhibitory effects of uremic material on nervous tissue transketolase, a thiamine-dependent enzyme of the pentose phosphate pathway which has been reported to have functional importance in the metabolism of myelinated nervous structures.

Authors

R. B. Sterzel, M. Semar, E. T. Lonergan, G. Treser, K. Lange