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Research Article Free access | 10.1172/JCI106709

Proximal tubular function in dogs with thoracic caval constriction

R. Brewer Auld, Edward A. Alexander, and Norman G. Levinsky

Dalhousie University Medical School, Halifax, Nova Scotia, Canada

Boston University School of Medicine, Boston, Massachusetts 02118

Boston University Medical Service, Boston City Hospital, Boston, Massachusetts 02118

Find articles by Auld, R. in: PubMed | Google Scholar

Dalhousie University Medical School, Halifax, Nova Scotia, Canada

Boston University School of Medicine, Boston, Massachusetts 02118

Boston University Medical Service, Boston City Hospital, Boston, Massachusetts 02118

Find articles by Alexander, E. in: PubMed | Google Scholar

Dalhousie University Medical School, Halifax, Nova Scotia, Canada

Boston University School of Medicine, Boston, Massachusetts 02118

Boston University Medical Service, Boston City Hospital, Boston, Massachusetts 02118

Find articles by Levinsky, N. in: PubMed | Google Scholar

Published October 1, 1971 - More info

Published in Volume 50, Issue 10 on October 1, 1971
J Clin Invest. 1971;50(10):2150–2158. https://doi.org/10.1172/JCI106709.
© 1971 The American Society for Clinical Investigation
Published October 1, 1971 - Version history
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Abstract

The effect of saline infusion on proximal sodium reabsorption was compared in normal dogs and in dogs with acute or chronic partial thoracic vena cava obstruction. After acute vena cava obstruction, proximal fractional sodium reabsorption rose by 74%. During continued caval obstruction, saline loading strikingly reduced proximal reabsorption but sodium excretion remained minimal. In chronic caval dogs, saline loading reduced proximal fractional sodium reabsorption by 31% but sodium excretion in the micropunctured kidney was only 41 μEq/min. After saline infusion in normal dogs, proximal fractional sodium reabsorption fell 39% while unilateral sodium excretion rose to 584 μEq/min.

Nephron filtration rate was also measured before and after saline loading in normal and chronic caval dogs in both repunctured and fresh tubules. There was a marked increase in nephron filtration rate in repunctured tubules and no change in freshly punctured tubules in both groups. The effect of saline loading on nephron filtration rate in normal and chronic caval dogs was similar, therefore, whether repunctured or fresh nephrons were considered.

We conclude that saline infusion depresses proximal sodium reabsorption in acute and chronic TVC dogs. Since saline loading markedly increases distal delivery without a concomitant natriuresis, enhanced distal reabsorption must play a major role in the sodium retention exhibited by chronic caval dogs. Redistribution of filtrate does not appear to be a factor in this sodium retention.

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