Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106707

Serum alkaline phosphatase in hypophosphatasia

Joseph B. Warshaw, John W. Littlefield, William H. Fishman, Norma R. Inglis, and Leo L. Stolbach

Children's Service, Massachusetts General Hospital, Boston, Massachusetts 02114

Shriners Burns Institute and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02114

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02114

Find articles by Warshaw, J. in: PubMed | Google Scholar

Children's Service, Massachusetts General Hospital, Boston, Massachusetts 02114

Shriners Burns Institute and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02114

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02114

Find articles by Littlefield, J. in: PubMed | Google Scholar

Children's Service, Massachusetts General Hospital, Boston, Massachusetts 02114

Shriners Burns Institute and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02114

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02114

Find articles by Fishman, W. in: PubMed | Google Scholar

Children's Service, Massachusetts General Hospital, Boston, Massachusetts 02114

Shriners Burns Institute and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02114

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02114

Find articles by Inglis, N. in: PubMed | Google Scholar

Children's Service, Massachusetts General Hospital, Boston, Massachusetts 02114

Shriners Burns Institute and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02114

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02114

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02114

Find articles by Stolbach, L. in: PubMed | Google Scholar

Published October 1, 1971 - More info

Published in Volume 50, Issue 10 on October 1, 1971
J Clin Invest. 1971;50(10):2137–2142. https://doi.org/10.1172/JCI106707.
© 1971 The American Society for Clinical Investigation
Published October 1, 1971 - Version history
View PDF
Abstract

It is recognized that serum alkaline phosphatase may reflect enzyme contributions from bone, liver, and intestine. We have investigated serum alkaline phosphatases in two siblings with hypophosphatasia. After administration of long-chain triglycerides, the major alkaline phosphatase component of their sera was shown to be of intestinal origin on the basis of inhibition by l-phenylalanine. Starch block electrophoresis suggested that there were other regions of l-phenylalanine-sensitive alkaline phosphatase in addition to the major slow-moving intestinal band. Medium-chain triglycerides which are absorbed by the portal route did not cause a similar augmentation of intestinal alkaline phosphatase activity. These studies indicate that serum levels of intestinal alkaline phosphatase are increased normally after long-chain fat feeding in hypophosphatasia and may be the major component of total serum alkaline phosphatase activity.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2137
page 2137
icon of scanned page 2138
page 2138
icon of scanned page 2139
page 2139
icon of scanned page 2140
page 2140
icon of scanned page 2141
page 2141
icon of scanned page 2142
page 2142
Version history
  • Version 1 (October 1, 1971): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts