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Amendment history:
  • Errata (December 1971)

Research Article Free access | 10.1172/JCI106647

On the Mechanism of Inhibition in Fluid Reabsorption by the Renal Proximal Tubule of the Volume-Expanded Rat

Barry M. Brenner, Julia L. Troy, Terrance M. Daugharty, I. F. Ueki, D. P. Nicholas, and C. F. Wong

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Find articles by Brenner, B. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Find articles by Troy, J. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Find articles by Daugharty, T. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Find articles by Ueki, I. in: PubMed | Google Scholar

Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

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Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94122

Find articles by Wong, C. in: PubMed | Google Scholar

Published August 1, 1971 - More info

Published in Volume 50, Issue 8 on August 1, 1971
J Clin Invest. 1971;50(8):1596–1602. https://doi.org/10.1172/JCI106647.
© 1971 The American Society for Clinical Investigation
Published August 1, 1971 - Version history
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Abstract

We undertook to determine the extent to which the inhibition in absolute proximal fluid reabsorption in response to expansion of extracellular volume with noncolloid-containing solutions is the result of concomitant reductions in postglomerular (efferent arteriolar) protein concentration. Selective elevation of efferent arteriolar oncotic pressure in volume-expanded rats (Ringer's 10% body weight) to levels slightly in excess of normal by microperfusion with 9-10% albumin-Ringer's solution nearly completely reversed the inhibition in absolute and fractional reabsorption in adjacent proximal tubules. In contrast, during similar microperfusion with a 6-7% albumin solution, no increase in proximal reabsorption was measured. We interpret these findings to indicate that the bulk of the inhibition in absolute proximal reabsorption in response to volume expansion with colloid-free solutions is causally mediated by the accompanying parallel decline in postglomerular vascular protein concentration.

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