Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106646

The Regulation of Aldosterone Secretion in Anephric Man

Francis Bayard, C. Robert Cooke, David J. Tiller, Inese Z. Beitins, Avinoam Kowarski, W. Gordon Walker, and Claude J. Migeon

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Bayard, F. in: PubMed | Google Scholar

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Cooke, C. in: PubMed | Google Scholar

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Tiller, D. in: PubMed | Google Scholar

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Beitins, I. in: PubMed | Google Scholar

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Kowarski, A. in: PubMed | Google Scholar

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Walker, W. in: PubMed | Google Scholar

Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The Harriet Lane Service of The Children's Medical and Surgical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205

The John Hopkins University School of Medicine, Baltimore, Maryland 21205

Find articles by Migeon, C. in: PubMed | Google Scholar

Published August 1, 1971 - More info

Published in Volume 50, Issue 8 on August 1, 1971
J Clin Invest. 1971;50(8):1585–1595. https://doi.org/10.1172/JCI106646.
© 1971 The American Society for Clinical Investigation
Published August 1, 1971 - Version history
View PDF
Abstract

The regulation of aldosterone secretion in anephric man was investigated in studies on nephrectomized patients who were being intermittently hemodialyzed while awaiting renal transplantation. The effects of supine and upright posture on the concentration of plasma aldosterone on the 1st day postdialysis and on a 3rd or 4th day postdialysis were compared to the effects of postural variation in normal subjects who were on a low sodium intake and on a high sodium intake. In contrast with the normal subjects who exhibited higher concentrations of plasma aldosterone after 2 hr of upright posture than in the supine position and low concentrations of plasma aldosterone on a high sodium intake, the anephric patients showed less consistent variations in plasma aldosterone due to changes in posture and exhibited higher concentrations of plasma aldosterone on the 3rd or 4th day postdialysis, despite an increase in body weight, than on the 1st day postdialysis.

The increase in the concentration of plasma aldosterone in the anephric patients between the 1st day postdialysis and the 3rd or 4th day postdialysis indicates that aldosterone secretion is not responding primarily, in this situation, to volume-related stimuli. There was a high degree of correlation between the concentration of plasma aldosterone and the corresponding levels of serum potassium concentration, which also rose significantly between the 1st day postdialysis and the 3rd or 4th day postdialysis. Furthermore, when potassium accumulation between dialyses was prevented in three of these patients, the concentration of plasma aldosterone fell to minimally detectable levels. The results of these studies suggest that the primary regulator of aldosterone secretion in the absence of the kidneys is potassium.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1585
page 1585
icon of scanned page 1586
page 1586
icon of scanned page 1587
page 1587
icon of scanned page 1588
page 1588
icon of scanned page 1589
page 1589
icon of scanned page 1590
page 1590
icon of scanned page 1591
page 1591
icon of scanned page 1592
page 1592
icon of scanned page 1593
page 1593
icon of scanned page 1594
page 1594
icon of scanned page 1595
page 1595
Version history
  • Version 1 (August 1, 1971): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts