Advertisement

Research Article Free access | 10.1172/JCI106621

Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs

Ole D. Mjøs

Institute for Experimental Medical Research, University of Oslo, Ullevaal Hospital, Oslo, Norway

Find articles by Mjøs, O. in: PubMed | Google Scholar

Published July 1, 1971 - More info

Published in Volume 50, Issue 7 on July 1, 1971
J Clin Invest. 1971;50(7):1386–1389. https://doi.org/10.1172/JCI106621.
© 1971 The American Society for Clinical Investigation
Published July 1, 1971 - Version history
View PDF
Abstract

Myocardial function and oxygen consumption (MV̇O2) were studied during increased myocardial uptake of free fatty acids (FFA) induced by intravenous infusion of a fat emulsion (Intralipid) after heparinization in anesthetized and intact dogs. During raised myocardial uptake of FFA, MV̇O2 increased in all experiments. On the average, MV̇O2 rose from 8.6 to 10.7 ml/min·100 g, or 26% (P < 0.001). This was mainly due to elevated myocardial oxygen extraction, as myocardial blood flow was unchanged, or increased slightly. In the recovery period, MV̇O2 returned to normal. Left ventricular pressure, the maximal rate of rise of left ventricular pressure (dP/dt), heart rate, and cardiac output remained unchanged during the raised myocardial uptake of FFA.

These experiments show that increased myocardial uptake of FFA in intact hearts was associated with augmented MV̇O2, despite unchanged mechanical activity.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (July 1, 1971): No description
Advertisement
Advertisement