Ventilatory mechanics and expiratory flow limitation during exercise in patients with obstructive lung disease

William A. Potter; Snorri Olafsson; Robert E. Hyatt

doi:10.1172/JCI106563

¹Mayo Clinic, the Mayo Foundation, and the Mayo Graduate School of Medicine, Rochester, Minnesota 55901

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¹Mayo Clinic, the Mayo Foundation, and the Mayo Graduate School of Medicine, Rochester, Minnesota 55901

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¹Mayo Clinic, the Mayo Foundation, and the Mayo Graduate School of Medicine, Rochester, Minnesota 55901

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Published in Volume 50, Issue 4 on April 1, 1971
J Clin Invest. 1971;50(4):910–919. https://doi.org/10.1172/JCI106563.
© 1971 The American Society for Clinical Investigation

Published April 1, 1971 - Version history

The interrelationships among transpulmonary pressure, flow, and volume during exhausting exercise were studied in 12 males with chronic obstructive lung disease. Expiratory pressure during exercise was compared with flow-limiting pressure (P_max) measured at rest. In 11 patients, expiratory pressure during exercise exceeded P_max, indicating that ventilation became mechanically inefficient. P_max values of the patients were lower than those of normal subjects. Evidence of expiratory flow augmentation during exercise was noted in two subjects. Since 10 subjects achieved maximal expiratory flow predicted from flow-volume curves when heart rate was not maximal, we conclude that exercise capacity in most subjects was clearly limited by the deranged ventilatory apparatus. Elevations in mean intrathoracic pressure during exercise also may interfere with venous return and impose an additional limitation.