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Research Article Free access | 10.1172/JCI106531

Complement-derived leukotactic factors in inflammatory synovial fluids of humans

Peter A. Ward and Nathan J. Zvaifler

Immunobiology Branch, Armed Forces Institute of Pathology, Washington, D. C. 20305

Department of Medicine, Georgetown University, School of Medicine, Washington, D. C. 20007

Find articles by Ward, P. in: JCI | PubMed | Google Scholar

Immunobiology Branch, Armed Forces Institute of Pathology, Washington, D. C. 20305

Department of Medicine, Georgetown University, School of Medicine, Washington, D. C. 20007

Find articles by Zvaifler, N. in: JCI | PubMed | Google Scholar

Published March 1, 1971 - More info

Published in Volume 50, Issue 3 on March 1, 1971
J Clin Invest. 1971;50(3):606–616. https://doi.org/10.1172/JCI106531.
© 1971 The American Society for Clinical Investigation
Published March 1, 1971 - Version history
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Abstract

A large per cent of rheumatoid synovial fluids contain chemotactic activity for rabbit granulocytes (neutrophilic). The chemotactic activity is, in large part, related to the fifth (C5) and sixth (C6) components of human complement; a combination of physical-chemical techniques indicates the activity to be attributable to C567 and C5a, a cleavage product of C5. Many rheumatoid synovial fluids contain a C5-cleaving enzyme which, on the basis of substrate specificity and susceptibility to inhibitors, is very similar to an enzyme extractable from lysosomal granules of human and rabbit granulocytes. Inflammatory nonrheumatoid synovial fluids contain chemotactic activity that is related to cleavage products (C3a) of the third component of human complement (C3). Also found in these fluids is a C3-cleaving enzyme capable of producing C3a. Of the other synovial fluids examined, lupus fluids were remarkable by their total lack of chemotactic activity. These findings record for the first time the presence of complement-derived chemotactic factors in pathological human fluids.

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