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Research Article Free access | 10.1172/JCI106458

Effects of parathyroid hormone on plasma and urinary adenosine 3′,5′-monophosphate in man

Neil I. Kaminsky, Arthur E. Broadus, Joel G. Hardman, Douglas J. Jones Jr., John H. Ball, Earl W. Sutherland, and Grant W. Liddle

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Kaminsky, N. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Broadus, A. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Hardman, J. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Jones, D. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Ball, J. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Sutherland, E. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

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Published December 1, 1970 - More info

Published in Volume 49, Issue 12 on December 1, 1970
J Clin Invest. 1970;49(12):2387–2395. https://doi.org/10.1172/JCI106458.
© 1970 The American Society for Clinical Investigation
Published December 1, 1970 - Version history
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Abstract

The effects of parathyroid hormone (PTH) on plasma and urinary adenosine 3′,5′-monophosphate (cyclic AMP) levels were studied in normal subjects. Under basal conditions normal adults have plasma concentrations of cyclic AMP ranging from 10 to 25 nmoles/liter and excrete from 1.5 to 5 μmoles of cyclic AMP per g of urinary creatinine. About one-half to two-thirds of the cyclic AMP excreted in the urine is derived from the plasma by glomerular filtration, and the remainder is produced by the kidney. Renal production of cyclic AMP is partly under the control of PTH. It can be suppressed by infusions of calcium and stimulated by infusions of the calcium chelating agent, EDTA. Infusions of PTH in doses up to 10 mU/kg per min were associated with dose-related increases both in urinary cyclic AMP and phosphate. Infusions of PTH in doses ranging from 20 to 80 mU/kg per min did not lead to any further increase in phosphaturia but did lead to further marked increases in urinary cyclic AMP. A modest increase in plasma cyclic AMP was noted when PTH was infused at 40 mU/kg per min. Anephric patients failed to show appreciable increases in plasma cyclic AMP in response to large doses of PTH but did show expected increases in response to glucagon. Surgical removal of parathyroid adenomas from nine patients with primary hyperparathyroidism was invariably followed by a decrease in urinary cyclic AMP, PTH, in large doses, and calcium infusion produced up to 2-fold increases in the other known naturally occurring cyclic nucleotide, guanosine 3′,5′-monophosphate (cyclic GMP).

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