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Research Article Free access | 10.1172/JCI106429

Potassium balance and the control of renin secretion

Jean E. Sealey, Irwin Clark, Marcia B. Bull, and John H. Laragh

Department of Medicine, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Biochemistry, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Orthopedic Surgery, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Find articles by Sealey, J. in: JCI | PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Biochemistry, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Orthopedic Surgery, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Find articles by Clark, I. in: JCI | PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Biochemistry, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Orthopedic Surgery, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Find articles by Bull, M. in: JCI | PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Biochemistry, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Department of Orthopedic Surgery, Columbia University, College of Physicians and Surgeons and the Presbyterian Hospital in the City of New York, New York 10032

Find articles by Laragh, J. in: JCI | PubMed | Google Scholar

Published November 1, 1970 - More info

Published in Volume 49, Issue 11 on November 1, 1970
J Clin Invest. 1970;49(11):2119–2127. https://doi.org/10.1172/JCI106429.
© 1970 The American Society for Clinical Investigation
Published November 1, 1970 - Version history
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Abstract

Plasma renin activity and renin substrate were measured in nine groups of rats which were maintained for 7 wk on diets in which the proportions of sodium and potassium were varied.

Balance data indicated that the highest dietary intake of potassium employed (92 mEq K+/100 g food) consistently induced sodium depletion. With less consistency, the highest sodium intake employed (52 mEq Na+/100 g food) tended to induce potassium depletion.

In accordance with previous reports, sodium deprivation induced significant increases in plasma renin activity. But the present results indicated that changes in potassium intake exerted a highly significant modulating influence on this characteristic response. The results describe an inverse relationship between potassium administration and the concurrent level of plasma renin activity. The highest serum renin levels of all occurred in the potassium-depleted animals and the usual renin response to sodium deprivation was virtually abolished in the presence of a high potassium diet.

Neither the suppressing effect of K+ administration nor the stimulating effect of K+ depletion on plasma renin activity could be explained in terms of any predicted changes in aldosterone secretion or observed changes in sodium balance. Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.

These studies point to an important role for potassium in the regulation of renin secretion. The results in turn raise the possibility that renin secretion per se may be importantly involved in effecting potassium conservation and potassium elimination. The means by which these interactions are finally mediated remain to be clarified.

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