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Usage Information

The effects of transport inhibitors on sodium outflux and influx in red blood cells: evidence for exchange diffusion
Michael J. Dunn
Michael J. Dunn
Published October 1, 1970
Citation Information: J Clin Invest. 1970;49(10):1804-1814. https://doi.org/10.1172/JCI106398.
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Research Article

The effects of transport inhibitors on sodium outflux and influx in red blood cells: evidence for exchange diffusion

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Abstract

Active sodium transport (outflux or efflux) in red blood cells generally has been measured by assessing the amount of outflux inhibited by digitalis glycosides (outflux-fraction I). The presence of a ouabain-uninhibited sodium outflux (outflux-fraction II) attributable either to a second active transport mechanism or to exchange diffusion has been the subject of recent investigations. In the present study a variety of transport inhibitors, including ouabain, ethacrynic acid, furosemide, oligomycin, and amiloride, were studied for their effects on these components of sodium transport in RBC.

Authors

Michael J. Dunn

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