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Research Article Free access | 10.1172/JCI106385

The effect of hydrocortisone on immunoglobulin metabolism

Arthur L. Levy and Thomas A. Waldmann

1Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

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1Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Waldmann, T. in: PubMed | Google Scholar

Published September 1, 1970 - More info

Published in Volume 49, Issue 9 on September 1, 1970
J Clin Invest. 1970;49(9):1679–1684. https://doi.org/10.1172/JCI106385.
© 1970 The American Society for Clinical Investigation
Published September 1, 1970 - Version history
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Abstract

The serum concentration of all subclasses of IgG (γ2A, γ2B, and γ1) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using 131I-labeled γ2A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.

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