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Usage Information

The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man
Scott M. Grundy, E. H. Ahrens Jr.
Scott M. Grundy, E. H. Ahrens Jr.
Published June 1, 1970
Citation Information: J Clin Invest. 1970;49(6):1135-1152. https://doi.org/10.1172/JCI106329.
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Research Article

The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man

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Abstract

Cholesterol balance studies were carried out in 11 patients with various types of hyperlipoproteinemia to determine the mechanism by which unsaturated fats lower plasma cholesterol. Unsaturated fats produced no increase in fecal endogenous neutral steroids in 10 of 11 patients and no decrease in absorption of exogenous cholesterol in 5 patients who received cholesterol in the diet. In 8 of 11 patients no changes occurred in excretion of bile acids during the period on unsaturated fat when plasma cholesterol was declining. However, in 3 of 11 patients small but significant increases in bile acid excretion were found during this transitional period; in 2 others increases also occurred after plasma cholesterol had become constant at lower levels on unsaturated fat.

Authors

Scott M. Grundy, E. H. Ahrens Jr.

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 223 6
PDF 55 24
Scanned page 781 60
Citation downloads 66 0
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Total Views 1,215
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