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Research Article Free access | 10.1172/JCI106310
Research Service, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, School of Medicine, University of California, San Francisco, California 94122
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California 94122
Find articles by Lewis, R. in: JCI | PubMed | Google Scholar
Research Service, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, School of Medicine, University of California, San Francisco, California 94122
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California 94122
Find articles by Trager, W. in: JCI | PubMed | Google Scholar
Published May 1, 1970 - More info
After administration of the coumarin anticoagulant racemic warfarin to normal humans, seven fluorescent compounds were chromatographically separated from extracts of their urine. Four of these were identified using mass spectrometry, thin-layer chromatography, and ultraviolet absorption spectroscopy. One metabolic pathway, reduction of the acetonyl side chain of warfarin, resulted in the formation of a second asymmetric carbon atom, and two diastereoisomer alcohols were identified. These warfarin alcohols are structurally similar to pharmacologically active coumarin derivatives. They have not been reported in animal studies. In addition, 6- and 7-hydroxywarfarin were identified. These are the first studies to document the metabolic fate of warfarin in the normal human.
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