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Research Article Free access | 10.1172/JCI106263

Effect of colchicine on intestinal disaccharidases: correlation with biochemical aspects of cellular renewal

John J. Herbst, Ruth Hurwitz, Philip Sunshine, and Norman Kretchmer

Lt. J. P. Kennedy, Jr., Laboratories for Molecular Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305

Find articles by Herbst, J. in: PubMed | Google Scholar

Lt. J. P. Kennedy, Jr., Laboratories for Molecular Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305

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Lt. J. P. Kennedy, Jr., Laboratories for Molecular Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305

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Lt. J. P. Kennedy, Jr., Laboratories for Molecular Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305

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Published March 1, 1970 - More info

Published in Volume 49, Issue 3 on March 1, 1970
J Clin Invest. 1970;49(3):530–536. https://doi.org/10.1172/JCI106263.
© 1970 The American Society for Clinical Investigation
Published March 1, 1970 - Version history
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Abstract

There was a significant depression of the activities of intestinal lactase, invertase, and alkaline phosphatase in rats given drinking water containing 2.5 mg of colchicine per 100 ml. Activities of intestinal maltase, aspartate transcarbamylase, and dihydroorotase were not affected by the drug. Injection of colchicine (1 mg/kg) caused depression of intestinal invertase activity within 8 hr. Investigation of the effect of colchicine on the disaccharides in vitro demonstrated that invertase and maltase were not affected by concentrations up to 125 mg/100 ml. Intestinal lactase was inhibited by concentrations exceeding 5 mg/100 ml. Calculation of the concentration of colchicine present in the intestine, after a single injection, indicated that the in vivo effect of colchicine was not due to simple enzyme inhibition.

Histological examination showed an increase in crypt cells but no decrease in the length of the villi. Cellular migration along the villi, as well as activity of uridine kinase in intestinal mucosa, was increased in colchicine-treated rats. It was concluded that colchicine did not depress intestinal invertase, lactase, and alkaline phosphatase by decreasing cellular renewal, but rather it exerted its effect directly on the differentiated cells of the villus.

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