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Usage Information

Inheritance of human α1-acid glycoprotein (orosomucoid) variants
A. Myron Johnson, … , Karl Schmid, Chester A. Alper
A. Myron Johnson, … , Karl Schmid, Chester A. Alper
Published December 1, 1969
Citation Information: J Clin Invest. 1969;48(12):2293-2299. https://doi.org/10.1172/JCI106195.
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Research Article

Inheritance of human α1-acid glycoprotein (orosomucoid) variants

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Abstract

Although variants of sialic acid-free α1-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of α1-acid glycoprotein variants in family members are consistent with inheritance as autosomal traits with codominant expression. Gene frequencies have been determined for several ethnic groups. Of a total of 11 maternal-cord serum pairs, seven were discordant types, indicating that the fetus synthesizes α1-acid glycoprotein and confirming a previous report that there is no significant transplacental passage of this protein.

Authors

A. Myron Johnson, Karl Schmid, Chester A. Alper

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Usage data is cumulative from June 2024 through June 2025.

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PDF 47 13
Figure 0 1
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Citation downloads 101 0
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