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Research Article Free access | 10.1172/JCI106125

Metabolic clearance rate of radioiodinated human growth hormone in man

Donald P. Cameron, Henry G. Burger, Kevin J. Catt, and Alison Doig

Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004

Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052

Find articles by Cameron, D. in: PubMed | Google Scholar

Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004

Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052

Find articles by Burger, H. in: PubMed | Google Scholar

Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004

Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052

Find articles by Catt, K. in: PubMed | Google Scholar

Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004

Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052

Find articles by Doig, A. in: PubMed | Google Scholar

Published September 1, 1969 - More info

Published in Volume 48, Issue 9 on September 1, 1969
J Clin Invest. 1969;48(9):1600–1608. https://doi.org/10.1172/JCI106125.
© 1969 The American Society for Clinical Investigation
Published September 1, 1969 - Version history
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Abstract

The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant infusion studies. After single injection of highly purified radioiodinated HGH, the disappearance curve remained multiexponential during the period of study (4 hr). The shape of the curve was independent of the growth hormone preparation used. Similar disappearance curves were obtained with unlabeled HGH.

MCR values calculated from constant infusion studies were 203 ±7.8 liters/day per m2 and values derived from single injection studies agreed closely with this.

The multiexponential nature of the disappearance curve does not permit meaningful calculation of volume of distribution or half-time of disappearance.

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