Distribution and turnover of cholesterol in humans

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Abstract

The relationships between some parameters of cholesterol metabolism and body weight were studied in 22 subjects. Cholesterol-4-14C, complexed with plasma lipoprotein, was injected intravenously and from the resultant specific activity-time curves a number of indexes of cholesterol turnover were calculated. These were based on the two-pool model previously described by Goodman and Noble and included estimates of the sizes of the two pools, the production rate of cholesterol in the system, the rate constants for cholesterol removal from the two pools and transfer between the pools, and the metabolic clearance of cholesterol.

Authors

Paul J. Nestel, H. Malcolm Whyte, DeWitt S. Goodman