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Research Article Free access | 10.1172/JCI106043

Serum kynurenine in rheumatoid arthritis

Harry Spiera and Ramon Vallarino

1Department of Medicine, Mount Sinai School of Medicine of The City University of New York, New York 10029

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1Department of Medicine, Mount Sinai School of Medicine of The City University of New York, New York 10029

Find articles by Vallarino, R. in: PubMed | Google Scholar

Published May 1, 1969 - More info

Published in Volume 48, Issue 5 on May 1, 1969
J Clin Invest. 1969;48(5):856–859. https://doi.org/10.1172/JCI106043.
© 1969 The American Society for Clinical Investigation
Published May 1, 1969 - Version history
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Abstract

The concentration of kynurenine has been measured in the serum of patients with rheumatoid arthritis and in a control group. The mean serum concentration was 2.27 ± 0.688 μg/ml for patients with rheumatoid arthritis and 2.95 ± 0.825 μg/ml for the control group.

Kynurenine: creatinine clearance ratios were higher in the rheumatoid arthritis than in the control group. These data suggest that the increased urinary excretion of kynurenine by patients with rheumatoid arthritis is due at least in part to renal factors.

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