Usage Information

Hemoglobin Hasharon (α247 his(CD5)β2): a hemoglobin found in low concentration
S. Charache, … , A. M. Mondzac, U. Gessner
S. Charache, … , A. M. Mondzac, U. Gessner
Published May 1, 1969
Citation Information: J Clin Invest. 1969;48(5):834-847. https://doi.org/10.1172/JCI106041.
View: Text | PDF
Research Article

Hemoglobin Hasharon (α247 his(CD5)β2): a hemoglobin found in low concentration

Abstract

Hemoglobin Hasharon (α247 his(CD5)β2) was found to comprise only 16-19% of hemolysates of carriers. These heterozygotes appeared to have mild, compensated, hemolytic anemia. Hb Hasharon was more heat-labile than hemoglobins A, S, or C. Its specific activity was higher than that of Hb A after administration of 59Fe to two carriers. When hemoglobin synthesis by bone marrow cells was studied in vitro, about 18% of incorporated leucine appeared in the Hb Hasharon fraction. It is suggested that Hb Hasharon is unstable in vivo, and that mild hemolytic anemia and a relatively small decrease in its concentration in hemolysates result from its denaturation within red cells. Decreased synthesis, which appears to be the major cause of the small amount of abnormal hemoglobin, may protect heterozygotes from clinically significant hemolytic anemia.

Authors

S. Charache, A. M. Mondzac, U. Gessner

×

Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 540 166
PDF 99 100
Figure 0 3
Scanned page 916 73
Citation downloads 66 0
Totals 1,621 342
Total Views 1,963
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement