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Usage Information

Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels
Claude Lenfant, John Torrance, Eugenia English, Clement A. Finch, Cesar Reynafarje, Jose Ramos, Jose Faura
Claude Lenfant, John Torrance, Eugenia English, Clement A. Finch, Cesar Reynafarje, Jose Ramos, Jose Faura
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Research Article

Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels

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Abstract

The relationship between oxygen dissociation and 2,3-diphosphoglycerate (2,3-DPG) in the red cell has been studied in subjects moving from low to high altitude and vice versa. Within 24 hr following the change in altitude there was a change in hemoglobin affinity for oxygen; this modification therefore represents an important rapid adaptive mechanism to anoxia. A parallel change occurred in the organic phosphate content of the red cell. While this study does not provide direct evidence of a cause-effect relationship, the data strongly suggest that with anoxia, the observed rise in organic phosphate content of the red cell is responsible for increased availability of oxygen to tissues.

Authors

Claude Lenfant, John Torrance, Eugenia English, Clement A. Finch, Cesar Reynafarje, Jose Ramos, Jose Faura

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Usage data is cumulative from May 2025 through May 2026.

Usage JCI PMC
Text version 756 275
PDF 174 26
Scanned page 425 5
Citation downloads 188 0
Totals 1,543 306
Total Views 1,849
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