Abstract
Aldosterone metabolism has been shown to be altered in pregnancy. The increased conversion of intravenously administered aldosterone-3H to the acid-labile conjugate in the urine (aldosterone 18-glucuronide) has again been observed. The urinary yield of intravenously administered aldosterone-3H as aldosterone 18-glucuronide in 16 pregnant subjects of 13.4±0.9 (SE)% was significantly higher (P 0.001) than in 11 nonpregnant subjects (seven males and four females) of 7.3±0.5 (SE)%.
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