Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI105904

Genetic polymorphism of the third component of human complement (C′3)

Chester A. Alper and Richard P. Propp

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115

Blood Grouping Laboratory and the Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Alper, C. in: PubMed | Google Scholar

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115

Blood Grouping Laboratory and the Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Propp, R. in: PubMed | Google Scholar

Published September 1, 1968 - More info

Published in Volume 47, Issue 9 on September 1, 1968
J Clin Invest. 1968;47(9):2181–2191. https://doi.org/10.1172/JCI105904.
© 1968 The American Society for Clinical Investigation
Published September 1, 1968 - Version history
View PDF
Abstract

Polymorphism of human C′3 has been defined by prolonged agarose electrophoresis of fresh serum. At least four, and probably five, alleles have been identified by the electrophoretic mobilities of gene products. Inheritance of three alleles, F1 F, and S, is consistent with the autosomal condominant type. The inheritance of S1 is probably codominant and that of F0·8 is not known. Of the 15 phenotypes predicted by these alleles, eight have been observed.

The allotypes appear to differ in net surface charge at pH 8.6, but show no obvious differences in complement activity, in molecular size, or in binding of Ca++. The concentrations of the two gene products in serum from all known heterozygotes are approximately equal.

The S gene is most common in the three major races of man. The F gene is relatively common in Caucasians, less common in American Negroes, and relatively uncommon in Orientals.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2181
page 2181
icon of scanned page 2182
page 2182
icon of scanned page 2183
page 2183
icon of scanned page 2184
page 2184
icon of scanned page 2185
page 2185
icon of scanned page 2186
page 2186
icon of scanned page 2187
page 2187
icon of scanned page 2188
page 2188
icon of scanned page 2189
page 2189
icon of scanned page 2190
page 2190
icon of scanned page 2191
page 2191
Version history
  • Version 1 (September 1, 1968): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts