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Research Article Free access | 10.1172/JCI105899

Brain metabolism in uremic and adenosine-infused rats

Stanley Van Den Noort, Robert E. Eckel, Katherine Brine, and Jeffry T. Hrdlicka

1Department of Medicine, Division of Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106

Find articles by Van Den Noort, S. in: PubMed | Google Scholar

1Department of Medicine, Division of Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106

Find articles by Eckel, R. in: PubMed | Google Scholar

1Department of Medicine, Division of Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106

Find articles by Brine, K. in: PubMed | Google Scholar

1Department of Medicine, Division of Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106

Find articles by Hrdlicka, J. in: PubMed | Google Scholar

Published September 1, 1968 - More info

Published in Volume 47, Issue 9 on September 1, 1968
J Clin Invest. 1968;47(9):2133–2142. https://doi.org/10.1172/JCI105899.
© 1968 The American Society for Clinical Investigation
Published September 1, 1968 - Version history
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Abstract

Analyses of nucleotides and glycolytic intermediates were performed on perchlorate extracts of blood and quick-frozen brain from rats nephrectomized 48 hr previously, and from rats infused for 6 hr with adenosine or AMP. Blood nucleotides of acutely uremic rats were normal. Uremic brain showed an increase of creatine phosphate (CP), ATP, and glucose with a corresponding decrease in creatine, ADP, AMP, and lactate. Other nucleotide triphosphates were increased, but total adenine nucleotide in brain was unchanged. Uremic brain failed to use ATP or produce ADP, AMP, and lactate at normal rates when subjected to the stress of ischemic anoxia. Although levels of cation responsive ATPase in extracts of uremic brain were normal, the inhibition of glycolysis in the intact brain appeared to be due to a failure of ATP hydrolysis (a diminished ATPase activity). Adenosine infusion produced mild azotemia, marked hyperglycemia, an increase in blood ATP, and an increase in total blood adenine nucleotide. Brain from rats infused with adenosine or AMP also had high levels of ATP, creatine phosphate, and glucose, whereas levels of ADP, AMP, and lactate were low. However these brains responded with normal use of ATP and normal production of lactate when stimulated by ischemic anoxia.

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