Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI105880

Erythropoietic kinetics in sheep studied by means of induced changes in hemoglobin phenotype

Thomas G. Gabuzda, Marc A. Schuman, Ruth K. Silver, and Hugh B. Lewis

Cardeza Foundation, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107

New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania 19348

Find articles by Gabuzda, T. in: PubMed | Google Scholar

Cardeza Foundation, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107

New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania 19348

Find articles by Schuman, M. in: PubMed | Google Scholar

Cardeza Foundation, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107

New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania 19348

Find articles by Silver, R. in: PubMed | Google Scholar

Cardeza Foundation, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107

New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania 19348

Find articles by Lewis, H. in: PubMed | Google Scholar

Published August 1, 1968 - More info

Published in Volume 47, Issue 8 on August 1, 1968
J Clin Invest. 1968;47(8):1895–1904. https://doi.org/10.1172/JCI105880.
© 1968 The American Society for Clinical Investigation
Published August 1, 1968 - Version history
View PDF
Abstract

This investigation is concerned with the kinetics of the reciprocal relationship between sheep hemoglobin (Hb) A and Hb C formation in response to anemia. The relative synthesis of the hemoglobin types was assessed at various times in bone marrow erythroid cells incubated in vitro with 59Fe. The changeover from Hb A to Hb C formation lagged by about 3 days behind the development of anemia and was complete within about 11 days. After recovery from anemia the reciprocal change back to preanemic conditions proceeded at a much slower rate, Hb C formation gradually declining to unmeasurable levels over about 25 days.

Infusions of plasma with high erythropoietin titre induced the formation of relatively large quantities of Hb C in erythroid cells of nonanemic sheep, demonstrating the central importance of a humoral mechanism in the change of expression of the hemoglobin genes.

The following conclusions were drawn: hemoglobin phenotype is determined at a stem cell level. Erythroid stem cells appear to undergo gradual renewal. The identity of the plasma factor which induces Hb C formation is not yet known; it is not present in plasma from nonanemic sheep, and its production is not dependent upon hemoglobin genotype. If the plasma factor turns out to be erythropoietin, then this hormone must have an important influence on the pool of erythroid stem cells.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1895
page 1895
icon of scanned page 1896
page 1896
icon of scanned page 1897
page 1897
icon of scanned page 1898
page 1898
icon of scanned page 1899
page 1899
icon of scanned page 1900
page 1900
icon of scanned page 1901
page 1901
icon of scanned page 1902
page 1902
icon of scanned page 1903
page 1903
icon of scanned page 1904
page 1904
Version history
  • Version 1 (August 1, 1968): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts