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Research Article Free access | 10.1172/JCI105862

Antibody to human follicle-stimulating hormone: cross-reactivity with three other hormones

Sheldon Schlaff, Saul W. Rosen, and Jesse Roth

1Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

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1Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Find articles by Rosen, S. in: PubMed | Google Scholar

1Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Find articles by Roth, J. in: PubMed | Google Scholar

Published July 1, 1968 - More info

Published in Volume 47, Issue 7 on July 1, 1968
J Clin Invest. 1968;47(7):1722–1729. https://doi.org/10.1172/JCI105862.
© 1968 The American Society for Clinical Investigation
Published July 1, 1968 - Version history
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Abstract

Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-131I were produced in rabbits and guinea pigs by repeated injections of FSH. By 131I immunochemical methods, we found that at least 90% of the FSH-131I-binding antibody failed to distinguish the four human glycoprotein hormones: FSH, luteinizing hormone, chorionic gonadotropin, and thyrotropin, purified as well as endogenous hormone in plasma. Neither growth hormone, adrenocorticotropin, nor a variety of glycoproteins or animal plasmas were able to react with these antibodies.

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