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Research Article Free access | 10.1172/JCI105850

A study of urinary excretion of parathyroid hormone in man

John E. Bethune and Randolph A. Turpin

Department of Medicine, Los Angeles County—University of Southern California Medical Center, Los Angeles, California 90033

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Department of Medicine, Los Angeles County—University of Southern California Medical Center, Los Angeles, California 90033

Find articles by Turpin, R. in: PubMed | Google Scholar

Published July 1, 1968 - More info

Published in Volume 47, Issue 7 on July 1, 1968
J Clin Invest. 1968;47(7):1583–1589. https://doi.org/10.1172/JCI105850.
© 1968 The American Society for Clinical Investigation
Published July 1, 1968 - Version history
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Abstract

A procedure for bioassaying parathyroid hormone-like activity in human urine has been developed. 24-hr urine samples were concentrated with dry Sephadex G-25 and bioassayed in the young thyroparathyrocauterized mouse by the measurement of whole blood calcium. Recovery of biological activity and radioiodinated beef parathyroid hormone was over 80%. Normal subjects usually excreted less than 30 U (USP) of activity per day while 18 patients with proven primary hyperparathyroidism excreted a mean of 182 U/day (USP). The activity was not found in 7 patients with hypoparathyroidism or in 5 patients with carcinoma of the breast, but was present in 9 patients with uremia and in 5 with carcinoma of the lung and hypercalcemia.

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