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Research Article Free access | 10.1172/JCI105742

Kinetics of thrombopoiesis

Laurence A. Harker

Department of Medicine, University of Washington School of Medicine, Seattle, Washington

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Published March 1, 1968 - More info

Published in Volume 47, Issue 3 on March 1, 1968
J Clin Invest. 1968;47(3):458–465. https://doi.org/10.1172/JCI105742.
© 1968 The American Society for Clinical Investigation
Published March 1, 1968 - Version history
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Abstract

Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced thrombocytosis, normal platelet counts, and induced thrombocytopenia for 4- and 10-day periods. Thrombopoiesis, as measured by megakaryocytic mass and 35S incorporation into platelets, appeared to be regulated by the demand for circulating platelets. In addition, two mechanisms were operative in the alteration of thrombopoiesis. The first mechanism involved the regulation of endomitosis in the immature megakaryocytes which in turn determined the subsequent volume of platelet-producing cytoplasm. The second mechanism regulated the number of megakaryocytes formed from the precursor, “stem cell,” compartment.

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