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Research Article Free access | 10.1172/JCI105698

The Effects of Angiotensin II on Renal Water and Electrolyte Excretion in Normal and Caval Dogs

Jerome G. Porush, George J. Kaloyanides, Roy J. Cacciaguida, and Stanley M. Rosen

Department of Medicine, The Brookdale Hospital Center, Maimonides Hospital of Brooklyn, and State University of New York, Downstate Medical Center, Brooklyn, New York

‡

Work performed during the tenure of a U. S. Public Health Service postdoctoral research fellowship.

Address requests for reprints to Dr. Jerome G. Porush, Department of Medicine, Brookdale Hospital Center, Linden Boulevard and Rockaway Parkway, Brooklyn, N. Y. 11212.

*

Received for publication 10 April 1967 and in revised form 17 August 1967.

This investigation was supported by grants HE-07839 and HE-10914, from the National Heart Institute, National Institutes of Health, Bathesda, Md. Presented, in part, at the Third International Congress of Nephrology, 25-30 September 1966, Washington, D. C.

Find articles by Porush, J. in: PubMed | Google Scholar

Department of Medicine, The Brookdale Hospital Center, Maimonides Hospital of Brooklyn, and State University of New York, Downstate Medical Center, Brooklyn, New York

‡

Work performed during the tenure of a U. S. Public Health Service postdoctoral research fellowship.

Address requests for reprints to Dr. Jerome G. Porush, Department of Medicine, Brookdale Hospital Center, Linden Boulevard and Rockaway Parkway, Brooklyn, N. Y. 11212.

*

Received for publication 10 April 1967 and in revised form 17 August 1967.

This investigation was supported by grants HE-07839 and HE-10914, from the National Heart Institute, National Institutes of Health, Bathesda, Md. Presented, in part, at the Third International Congress of Nephrology, 25-30 September 1966, Washington, D. C.

Find articles by Kaloyanides, G. in: PubMed | Google Scholar

Department of Medicine, The Brookdale Hospital Center, Maimonides Hospital of Brooklyn, and State University of New York, Downstate Medical Center, Brooklyn, New York

‡

Work performed during the tenure of a U. S. Public Health Service postdoctoral research fellowship.

Address requests for reprints to Dr. Jerome G. Porush, Department of Medicine, Brookdale Hospital Center, Linden Boulevard and Rockaway Parkway, Brooklyn, N. Y. 11212.

*

Received for publication 10 April 1967 and in revised form 17 August 1967.

This investigation was supported by grants HE-07839 and HE-10914, from the National Heart Institute, National Institutes of Health, Bathesda, Md. Presented, in part, at the Third International Congress of Nephrology, 25-30 September 1966, Washington, D. C.

Find articles by Cacciaguida, R. in: PubMed | Google Scholar

Department of Medicine, The Brookdale Hospital Center, Maimonides Hospital of Brooklyn, and State University of New York, Downstate Medical Center, Brooklyn, New York

‡

Work performed during the tenure of a U. S. Public Health Service postdoctoral research fellowship.

Address requests for reprints to Dr. Jerome G. Porush, Department of Medicine, Brookdale Hospital Center, Linden Boulevard and Rockaway Parkway, Brooklyn, N. Y. 11212.

*

Received for publication 10 April 1967 and in revised form 17 August 1967.

This investigation was supported by grants HE-07839 and HE-10914, from the National Heart Institute, National Institutes of Health, Bathesda, Md. Presented, in part, at the Third International Congress of Nephrology, 25-30 September 1966, Washington, D. C.

Find articles by Rosen, S. in: PubMed | Google Scholar

Published December 1, 1967 - More info

Published in Volume 46, Issue 12 on December 1, 1967
J Clin Invest. 1967;46(12):2109–2122. https://doi.org/10.1172/JCI105698.
© 1967 The American Society for Clinical Investigation
Published December 1, 1967 - Version history
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Abstract

The effects of intravenous administration of angiotensin II on renal water and electrolyte excretion were examined during hydropenia, water diuresis, and hypotonic saline diuresis in anesthetized normal dogs and dogs with thoracic inferior vena cava constriction and ascites (caval dogs). The effects of unilateral renal artery infusion of a subpressor dose were also examined.

During hydropenia angiotensin produced a decrease in tubular sodium reabsorption, with a considerably greater natriuresis in caval dogs, and associated with a decrease in free water reabsorption (TcH2O). Water and hypotonic saline diuresis resulted in an augmented angiotensin natriuresis, with a greater effect still observed in caval dogs. In these experiments free water excretion (CH2O) was limited to 8-10% of the glomerular filtration rate (GFR), although distal sodium load increased in every instance. In the renal artery infusion experiments a significant ipsilateral decrease in tubular sodium reabsorption was induced, particularly in caval dogs.

These findings indicate that angiotensin has a direct effect on renal sodium reabsorption unrelated to a systemic circulatory alteration. The attenuation or prevention of the falls in GFR and effective renal plasma flow (ERPF) usually induced by angiotensin may partially account for the greater natriuretic response in caval dogs and the augmentation during water or hypotonic saline diuresis. However, a correlation between renal hemodynamics and the degree of natriuresis induced was not always present and, furthermore, GFR and ERPF decreased significantly during the intrarenal artery infusion experiments. Therefore, the present experiments indicate that another mechanism is operative in the control of the angiotensin natriuresis and suggest that alterations in intrarenal hemodynamics may play a role.

The decrease in TcH2O and the apparent limitation of CH2O associated with an increase in distal sodium load localize the site of action of angiotensin to the ascending limb of Henle's loop and the proximal tubule.

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